{"id":2663,"date":"2024-12-18T19:21:40","date_gmt":"2024-12-18T19:21:40","guid":{"rendered":"https:\/\/237check.org\/?p=2663"},"modified":"2025-01-22T11:42:17","modified_gmt":"2025-01-22T11:42:17","slug":"does-doliprane-contain-a-substance-that-feminizes-males-from-the-placenta","status":"publish","type":"post","link":"https:\/\/237check.org\/fr\/2024\/12\/18\/does-doliprane-contain-a-substance-that-feminizes-males-from-the-placenta\/","title":{"rendered":"Does Doliprane contain a substance that Feminizes Males from the placenta?"},"content":{"rendered":"\n

On December 4, <\/em><\/strong>a claim<\/em><\/strong><\/a> circulated on X as a comment, alleging that Doliprane, a popular brand of paracetamol \u201ccontains a substance which can feminize men\u201d. This claim has sparked considerable concern and confusion particularly on social media. The claim has a reach of 49,200 views in a context where proliferation of medical claims on social media poses significant risks to public health. Misinformation spreads rapidly, leading to delayed diagnosis, misdiagnosis, or inappropriate treatment.<\/em><\/strong><\/p>\n\n\n\n

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The Claim<\/strong><\/h3>\n\n\n\n

The assertion is that Doliprane contains chemicals that interfere with male hormones, leading to \u201cfeminization\u201d. According to Science Direct<\/a>, Feminization occurs when maternally inherited symbionts block the production or action of masculinizing hormones. By causing genetic males to become female.\u00a0<\/p>\n\n\n\n

Also according to https:\/\/www.vocabulary.com\/dictionary\/feminisation<\/a>, feminization is the process of becoming feminized; the development of female characteristics (loss of facial hair or breast enlargement) in a male because of hormonal disorders or castration.<\/p>\n\n\n\n

According to Pharmashopi<\/a>, Doliprane is a widely marketed brand of paracetamol. It is the same active ingredient as generic paracetamol, but with a specific brand name. Doliprane is available in different forms, such as tablets, capsules, suppositories and syrups, which gives it a wider variety of options for patients. According to PharmaGod <\/a>(Doliprane 1000 mg comprim\u00e9) is reserved for adults and children weighing at least\u00a0 50 kg or more. The article also warns that exceeding the prescribed dose can destroy the liver<\/p>\n\n\n\n

These are some comments and Posts related to the feminization\u2019 effect of Doliprane:<\/p>\n\n\n\n

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Verification<\/strong><\/h3>\n\n\n\n

According to a research carried out by NICS (The National Institute for Clinical Studies), presented in this article\ufeff \u201cIs paracetamol use in pregnancy harmful for male babies?<\/a>\u201d,\u00a0 \u201cTaking the painkiller paracetamol in pregnancy for a week or more could potentially have effects on a developing male foetus<\/em> that is beyond the prescribed use\u201d https:\/\/www.theguardian.com\/lifeandstyle\/2015\/may\/20\/paracetamol-use-pregnancy-male-foetus-testosterone-study<\/a> . Findings<\/a> in epidemiological studies also suggest that maternal intake of paracetamol during pregnancy may be associated with male reproductive health. For example, maternal intake of paracetamol during pregnancy has been associated with congenital cryptorchidism, a common male genital birth defect where one or both testes fail to descend into the scrotum. Maternal intake of paracetamol during pregnancy was not clearly associated with biomarkers of male fecundity in adult sons; however, prolonged exposure might impair semen characteristics, warranting further investigation.<\/p>\n\n\n\n

There is no reason to think that taking the painkillers for a day could cause any problem, they say \u2013 but a study involving a mouse model, grafted with human tissue and given hormones to imitate the state of pregnancy, found the drug lowered testosterone levels over the course of a week.<\/p>\n\n\n\n

Pregnant women who take the painkiller paracetamol regularly for long periods may put their unborn sons\u2019 testosterone levels at risk, leading to possible reproductive problems later in life, researchers said. In a study (https:\/\/www.analesdepediatria.org<\/a>) using mice with grafts of human tissue, the scientists found that a week\u2019s paracetamol treatment led to a sharp fall in the production of testosterone, a hormone that is critical to men\u2019s life-long health.<\/p>\n\n\n\n

\u201cWe would advise that pregnant women should follow current guidance that the painkiller be taken at the lowest effective dose for the shortest possible time<\/em>,\u201d said Rod Mitchell, a clinical research fellow at Edinburgh University. The study<\/a>, published in the journal Science Translational Medicine, tested the effect of paracetamol on testosterone production in mice with grafts of human testicular tissue designed to mimic how testes develop and function in pregnancy. Mitchell\u2019s team gave the mice a typical daily dose of paracetamol over a period of either 24 hours or seven days and then measured the amount of testosterone produced by the human tissue an hour after the final dose of paracetamol. After 24 hours of paracetamol treatment, they found no effect on testosterone production, but after seven days of exposure, the amount of testosterone fell by 45 percent.<\/p>\n\n\n\n

To find more, we contacted Dr. Charles FOKUNANG\u00a0 P.h.D. in PHYTOPATHOLOGY who has made a scientific contribution worldwide in Phytopathology. He gives his take on whether Doliprane Feminizes Males by saying that Paracetamol (acetaminophen) is the preferred antipyretic\/analgesic for pregnant women as it is believed there are no adverse fetal effects at the recommended dose. However, emerging evidence suggests that intrauterine paracetamol exposure may be associated with certain urogenital\/reproductive disorders in the offspring. In a mini-review titled Maternal Paracetamol Intake During Pregnancy-Impacts on Offspring Reproductive Development<\/a>, it describes human fetal sex development and possible pharmacological mechanisms by which paracetamol may disrupt this process, including reduced testicular production of testosterone and\/or insulin-like peptide.\u00a0<\/p>\n\n\n\n

We review the available epidemiological literature on associations between maternal paracetamol exposure and offspring sexual development. We focused ourselves on three epidemiological studies :\u00a0<\/p>\n\n\n\n